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M94A0271.TXT
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1994-10-08
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Document 0271
DOCN M94A0271
TI Management of systemic manifestations of fungal disease in patients with
AIDS.
DT 9412
AU Stevens DA; Department of Medicine, Santa Clara Valley Medical Center,
San; Jose, CA 95128-2699.
SO J Am Acad Dermatol. 1994 Sep;31(3 Pt 2):S64-7. Unique Identifier :
AIDSLINE MED/94358253
AB In patients with AIDS with cryptococcosis, prompt diagnosis is
essential. Poor results with conventional therapy (amphotericin-5FC)
have led to exploration of the azoles. Both fluconazole and itraconazole
have given good short-term results with less toxicity. However, cure is
achieved far less often than in other compromised hosts. Fluconazole is
also useful to prevent relapse after successful initial amphotericin
therapy, particularly from genitourinary foci. In both histoplasmosis
and aspergillosis, itraconazole has produced impressive therapeutic
results, and in histoplasmosis, secondary prophylaxis as well. In
coccidioidomycosis results thus far have not been better than
conventional amphotericin therapy, especially in initial treatment.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Amphotericin
B/*THERAPEUTIC USE Coccidioidomycosis/COMPLICATIONS/*DRUG
THERAPY/EPIDEMIOLOGY/ IMMUNOLOGY Cryptococcosis/COMPLICATIONS/*DRUG
THERAPY/EPIDEMIOLOGY/ IMMUNOLOGY Drug Therapy, Combination
Fluconazole/*THERAPEUTIC USE Histoplasmosis/COMPLICATIONS/*DRUG
THERAPY/EPIDEMIOLOGY/ IMMUNOLOGY Human Itraconazole/*THERAPEUTIC USE
Meningitis, Cryptococcal/COMPLICATIONS/DRUG THERAPY/EPIDEMIOLOGY/
IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).